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NASH CRN investigators have recently published an article in The New England Journal of Medicine that shows a significant effect of vitamin E (800 IU / day) in improving liver histology in patients with NASH. In a study presented at ACG 2010 Meeting, Changes in insulin resistance in adipose tissue correlated with changes in liver histology in patients with Nash, who participated in the test Piven, Lauren Bell, Ph.D. and his colleagues at Indiana University School of Medicine studied whether changes in insulin resistance are responsible for the improvement of liver histology observed with vitamin E.
Claudia O. Zein, MD, and colleagues at the Veterans Affairs Medical Center in Cleveland and the Cleveland Clinic in Cleveland, OH double-blind, randomized, placebo-controlled trial of pentoxifylline in patients with NASH to assess the best levels of transaminases and improvement in the characteristics histological NASH as measured by the NAFLD activity score (NAS). The NAS score measures of disease activity and is derived from the sum of separate scores for fat, inflammation and swelling of the liver.
Improve Pentoxifyline progressive liver disease NASH compared to placebo
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Two studies presented at the 75 th Annual Scientific Meeting of the American College of Gastroenterology examined the effectiveness of potential treatments for NASH, an evaluation of pentoxifylline, a known drug with a safety profile that inhibits release of TNF and other mechanisms, and separate analysis of pioglitazone, an insulin sensitizer, compared to vitamin E. He noted that doctors should investigate suspicions and hepatic steatosis in patients who are at high risk, including those who are overweight, diabetic or have other elements of the metabolic syndrome.The study Pentoxifyline improves the nonalcoholic steatohepatitis: results of a double-blind, randomized, placebo-controlled, found that after one year, an improvement of 30 % or more starting ALT levels was observed in a significantly more patients taking pentoxifylline compared to placebo (p = 0.